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Enzyme paves the way for the spread of cancer cells to bones
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The spread of breast cancer to the bone affects approximately 85% of patients with advanced disease, and renders them largely untreatable. Researchers at BRIC (University of Copenhagen) and the University of Sheffield UK have uncovered how a certain enzyme, produced by cancer cells in breast cancer patients, plays a central role in helping the spread of cancer cells to the bones. By blocking this enzyme, it is possible to prevent the cancer cells from growing in the bone and thereby save lives.
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News
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Digital ‘Rosetta Stone’ Decrypts How Mutations Rewire Cancer Cells
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Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments.
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News
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Supercomputing Accelerates Path to Cancer Predictions and Treatment
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Quantitative bioinformatics studies utilizing genomics, proteomics and imaging experiments require the integration of vast amounts of data in order to gain new insights from large population data sets. In an effort to solve some of life science’s most complex questions, The Linding Laboratory in Denmark partnered with HPE/SGI to further its research at the Biotech Research and Innovation Centre (BRIC), University of Copenhagen and extract deeper insights into areas such as cell and cancer biology using high performance computing (HPC).
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Press
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Computational approaches to identify functional genetic variants in cancer genomes.
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Nature Methods 2013 Jul 30;10(8):723-9.
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Publications
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Linding Lab, BRIC & DTU [2011-2018]
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Global characterization of signalling networks associated with tamoxifen resistance in breast cancer.
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FEBS Journal 2013 Jul 22.
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Publications
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Linding Lab, BRIC & DTU [2011-2018]
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Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling.
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Cell. 2015 Sep 16. pii: S0092-8674(15)01108-3. doi: 10.1016/j.cell.2015.08.056.
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Linding Lab, BRIC & DTU [2011-2018]
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Unmasking Determinants of Specificity in the Human Kinome.
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Cell. 2015 Sep 16. pii: S0092-8674(15)01109-5. doi: 10.1016/j.cell.2015.08.057.
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Linding Lab, BRIC & DTU [2011-2018]
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Cancer systems biology: Harnessing off-target effects.
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Nature Chemical Biology 2017 Nov 21;13(12):1204-1205. doi: 10.1038/nchembio.2519.
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Publications
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Linding Lab, BRIC & DTU [2011-2018]
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Bowhead: Bayesian modelling of cell velocity during concerted cell migration.
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PLoS Comput Biol. 2018 Jan 8;14(1):e1005900. doi: 10.1371/journal.pcbi.1005900.
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Publications
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Linding Lab, BRIC & DTU [2011-2018]
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Farnesylated heat shock protein 40 is a component of membrane-bound RISC in Arabidopsis.
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J Biol Chem. 2018 Oct 26;293(43):16608-16622. doi: 10.1074/jbc.RA118.003887.
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Publications
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Linding Lab, BRIC & DTU [2011-2018]
