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High-dose oncogenic PIK3CA drives constitutive cellular stemness through self-sustained TGFβ pathway activation
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PREPRINT
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Linding Lab, REWIRE, HUB [2019-present]
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Global view of the RAF-MEK-ERK module and its immediate downstream effectors.
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Sci Rep. 2019 Jul 26;9(1):10865. doi: 10.1038/s41598-019-47245-x.
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Linding Lab, REWIRE, HUB [2019-present]
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Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs.
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Elife. 2019 May 24;8. pii: e44635. doi: 10.7554/eLife.44635.
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Linding Lab, BRIC & DTU [2011-2018]
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Probability-based detection of phosphoproteomic uncertainty reveals rare signaling events driven by oncogenic kinase gene fusion
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PREPRINT
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Linding Lab, REWIRE, HUB [2019-present]
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Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.
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PLoS Biology 2019 Mar 21;17(3):e2006540. doi: 10.1371/journal.pbio.2006540.
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Linding Lab, BRIC & DTU [2011-2018]
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Farnesylated heat shock protein 40 is a component of membrane-bound RISC in Arabidopsis.
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J Biol Chem. 2018 Oct 26;293(43):16608-16622. doi: 10.1074/jbc.RA118.003887.
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Linding Lab, BRIC & DTU [2011-2018]
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Deep Neural Networks Identify Signaling Mechanisms of ErbB-Family Drug Resistance From a Continuous Cell Morphology State Space
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PREPRINT
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Linding Lab, REWIRE, HUB [2019-present]
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Bowhead: Bayesian modelling of cell velocity during concerted cell migration.
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PLoS Comput Biol. 2018 Jan 8;14(1):e1005900. doi: 10.1371/journal.pcbi.1005900.
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Linding Lab, BRIC & DTU [2011-2018]
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Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments
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Cell Reports 2017 Sep 19;20(12):2784-2791. doi: 10.1016/j.celrep.2017.08.095.
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Linding Lab, BRIC & DTU [2011-2018]
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Digital ‘Rosetta Stone’ Decrypts How Mutations Rewire Cancer Cells
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Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments.
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