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Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.
PLoS Biology 2019 Mar 21;17(3):e2006540. doi: 10.1371/journal.pbio.2006540.
Located in Publications / Linding Lab, BRIC & DTU [2011-2018]
Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs.
Elife. 2019 May 24;8. pii: e44635. doi: 10.7554/eLife.44635.
Located in Publications / Linding Lab, BRIC & DTU [2011-2018]
Computational approaches to identify functional genetic variants in cancer genomes.
Nature Methods 2013 Jul 30;10(8):723-9.
Located in Publications / Linding Lab, BRIC & DTU [2011-2018]
CoreFlow: a computational platform for integration, analysis and modeling of complex biological data.
J Proteomics. 2014 Apr 4;100:167-73.
Located in Publications / Linding Lab, BRIC & DTU [2011-2018]
Deep Neural Networks Identify Signaling Mechanisms of ErbB-Family Drug Resistance From a Continuous Cell Morphology State Space
PREPRINT
Located in Publications / Linding Lab, REWIRE, HUB [2019-present]
Digital ‘Rosetta Stone’ Decrypts How Mutations Rewire Cancer Cells
Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments.
Located in News
Directional and quantitative phosphorylation networks.
Brief Funct Genomic Proteomic. 2008 Jan;7(1):17-26. Epub 2008 Feb 12.
Located in Publications / Linding Lab, ICR [work from 2007-2010]
Dissecting the interface between signaling and transcriptional regulation in human B cells.
Pac Symp Biocomput. 2009:264-75.
Located in Publications / Linding Lab, ICR [work from 2007-2010]
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.
Mol Cell. 2010 Oct 8;40(1):34-49.
Located in Publications / Linding Lab, ICR [work from 2007-2010]
Dr Linding, SLRI & MIT [work from 2005-2007]
Dr Rune Lindings publications from SLRI (Toronto, Canada) and MIT (Boston, USA).
Located in Publications