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Linding Lab, ICR [work from 2007-2010]

Publications of the Cellular & Molecular Logic Team, Integrative network biology initiative (INBi) Section of Cell and Molecular Biology, The Institute of Cancer Research (ICR)
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.
Mol Cell. 2010 Oct 8;40(1):34-49.
(R)evolution of Complex Regulatory Systems
Sci Signal. 2010 Jun 22;3(127):eg4.
Multivariate signal integration
Nat Rev Mol Cell Biol. 2010 May 6. [Epub ahead of print]
Roles of "junk phosphorylation" in modulating biomolecular association of phosphorylated proteins?
Cell Cycle. 2010 Apr 28;9(7). [Epub ahead of print]
Simplistic pathways or complex networks?
Curr Opin Genet Dev. 2010 Jan 20. [Epub ahead of print]
Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin–Expressing Cells.
Science. 2009 Dec 11;326(5959):1502-9.
Network-based drugs and biomarkers.
J Pathol. 2009 Nov 17. [Epub ahead of print]
Experimental and computational tools useful for (re)construction of dynamic kinase-substrate networks.
Proteomics. 2009 Oct 15. [Epub ahead of print]
Phosphorylation dynamics during early differentiation of human embryonic stem cells.
Cell Stem Cell. 2009 Aug 7;5(2):214-26.
Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases.
Sci Signal. 2009 Jul 28;2(81):ra39.
Positive selection of tyrosine loss in metazoan evolution.
Science. 2009 Sep 25;325(5948):1686-8. Epub 2009 Jul 9.
Dissecting the interface between signaling and transcriptional regulation in human B cells.
Pac Symp Biocomput. 2009:264-75.
Dynamic modularity in protein interaction networks predicts breast cancer outcome.
Nat Biotechnol. 2009 Feb;27(2):199-204. Epub 2009 Feb 1.
A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G(2)/M DNA Damage Checkpoint.
PLoS Biol. 2010 Jan 26;8(1):e1000287.
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds.
Science. 2008 Oct 17;322(5900):453-6.
Linear motif atlas for phosphorylation-dependent signaling.
Sci Signal. 2008 Sep 2;1(35):ra2.
Network medicine.
FEBS Lett. 2008 Apr 9;582(8):1266-70. Epub 2008 Feb 20.
Directional and quantitative phosphorylation networks.
Brief Funct Genomic Proteomic. 2008 Jan;7(1):17-26. Epub 2008 Feb 12.