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Selected Publications

Collection of selected publications
Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin–Expressing Cells.
Science. 2009 Dec 11;326(5959):1502-9.
Digital ‘Rosetta Stone’ Decrypts How Mutations Rewire Cancer Cells
Scientists have discovered how genetic cancer mutations systematically attack the networks controlling human cells, knowledge critical for the future development of personalized precision cancer treatments.
Protein disorder prediction: implications for structural proteomics.
Structure. 2003 Nov;11(11):1453-9.
Systematic discovery of new recognition peptides mediating protein interaction networks.
PLoS Biol. 2005 Dec;3(12):e405. Epub 2005 Nov 15.
ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins.
Nucleic Acids Res. 2003 Jul 1;31(13):3625-30.
GlobPlot: Exploring protein sequences for globularity and disorder.
Nucleic Acids Res. 2003 Jul 1;31(13):3701-8.
Synthetic modular systems - reverse engineering of signal transduction.
FEBS Lett. 2005 Mar 21;579(8):1808-14.
Navigating cancer network attractors for tumor-specific therapy
Nature Biotechnology 30, 842–848 (2012)
Cells, shared memory and breaking the PTM code
Molecular Systems Biology 8 Article number: 598 doi:10.1038/msb.2012.33
Network Medicine Strikes a Blow against Breast Cancer
Cell. 2012 May 11;149(4):731-3.
Response to Comment on “Positive Selection of Tyrosine Loss in Metazoan Evolution”
Science 20 May 2011: Vol. 332 no. 6032 p. 917
Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling.
Cell. 2015 Sep 16. pii: S0092-8674(15)01108-3. doi: 10.1016/j.cell.2015.08.056.
Unmasking Determinants of Specificity in the Human Kinome.
Cell. 2015 Sep 16. pii: S0092-8674(15)01109-5. doi: 10.1016/j.cell.2015.08.057.
Bowhead: Bayesian modelling of cell velocity during concerted cell migration.
PLoS Comput Biol. 2018 Jan 8;14(1):e1005900. doi: 10.1371/journal.pcbi.1005900.
Farnesylated heat shock protein 40 is a component of membrane-bound RISC in Arabidopsis.
J Biol Chem. 2018 Oct 26;293(43):16608-16622. doi: 10.1074/jbc.RA118.003887.
Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.
PLoS Biology 2019 Mar 21;17(3):e2006540. doi: 10.1371/journal.pbio.2006540.
Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs.
Elife. 2019 May 24;8. pii: e44635. doi: 10.7554/eLife.44635.
Global view of the RAF-MEK-ERK module and its immediate downstream effectors.
Sci Rep. 2019 Jul 26;9(1):10865. doi: 10.1038/s41598-019-47245-x.
Probability-based detection of phosphoproteomic uncertainty reveals rare signaling events driven by oncogenic kinase gene fusion
High-dose oncogenic PIK3CA drives constitutive cellular stemness through self-sustained TGFβ pathway activation